In 2001, Jay-z released The Blueprint which was later considered by many to be one of hip hop's "classic" albums, receiving the coveted 5 mic review from The Source magazine. Released during the wake of September 11 attacks, the album managed to debut at number one on the Billboard 200, selling more than 427,000 units; the album's success was overshadowed by the tragic event. The Blueprint has been certified two-time Platinum in the United States. This album was the first since his breakthrough album Vol. 2... Hard Knock Life not to feature Amil, who was dropped in late 2000 because of a feud between Jay-Z/Roc-A-Fella and herself, caused by her meager album sales and her weight gain.

The Blueprint was applauded for its production and the balance of "mainstream" and "hardcore" rap, receiving recognition from both audiences. Eminem was the only guest rapper on the album, producing and rapping on the single "Renegade" (Biz Markie, Slick Rick and Q-Tip were also guests, but only contributed hooks to the song "Girls, Girls, Girls"). Four of the thirteen tracks on the album were produced by Kanye West and represents one of West's first major breaks in the industry. The Blueprint also includes the popular "Izzo (H.O.V.A.)" and "Takeover", a song that takes on rivals Prodigy of Mobb Deep and Nas.